GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs10760706 | 1 | rs4585797 | chr9:102674147 | STX17 | chr9:102668915-102736817:+ | -0.17 | -4.29 | 2.17E-5 | Alopecia areata |
| THCA | cis | rs7665090 | 1 | rs4586937 | chr4:103556462 | NFKB1 | chr4:103422486-103538458:+ | -0.14 | -3.91 | 0.000105 | Primary biliary cirrhosis |
| THCA | cis | rs465969 | 1 | rs459048 | chr6:111689632 | KIAA1919 | chr6:111580482-111590259:+ | 0.48 | 5.6 | 3.62E-8 | Psoriasis |
| THCA | cis | rs1398024 | 1 | rs4590755 | chr10:23664813 | C10orf67 | chr10:23605521-23633772:- | -0.24 | -4.69 | 3.61E-6 | Crohn's disease and sarcoidosis (combined) |
| THCA | cis | rs11825709 | 1 | rs4590831 | chr11:93640908 | HEPHL1 | chr11:93754378-93847374:+ | -0.47 | -4.09 | 5.14E-5 | Obesity-related traits |
| THCA | cis | rs2143950 | 1 | rs4594164 | chr14:35509571 | FAM177A1 | chr14:35514113-35552587:+ | -0.22 | -4.19 | 3.33E-5 | Atopic dermatitis |
| THCA | cis | rs2143950 | 1 | rs4594164 | chr14:35509571 | KIAA0391 | chr14:35591776-35786673:+ | 0.29 | 5.32 | 1.6E-7 | Atopic dermatitis |
| THCA | cis | rs2143950 | 1 | rs4594164 | chr14:35509571 | PPP2R3C | chr14:35554679-35591679:- | 0.52 | 9.83 | 6.81E-21 | Atopic dermatitis |
| THCA | cis | rs459482 | 1 | rs459498 | chr21:42795027 | MX1 | chr21:42792520-42831140:+ | -0.19 | -3.76 | 0.00019 | IgG glycosylation |
| THCA | cis | rs459482 | 1 | rs459498 | chr21:42795027 | TFF2 | chr21:43766469-43771208:- | -0.13 | -3.42 | 0.00067 | IgG glycosylation |
| THCA | cis | rs7923609 | 1 | rs4595427 | chr10:65012944 | NRBF2 | chr10:64893007-64914785:+ | -0.28 | -6.73 | 4.85E-11 | Educational attainment;Liver enzyme levels (alkaline phosphatase) |
| THCA | cis | rs4808801 | 1 | rs4595905 | chr19:18547305 | ELL | chr19:18553475-18632937:- | -0.25 | -6.49 | 2.2E-10 | Breast cancer |
| THCA | cis | rs4808801 | 1 | rs4595905 | chr19:18547305 | ISYNA1 | chr19:18545625-18548943:- | 0.13 | 4.8 | 2.12E-6 | Breast cancer |
| THCA | cis | rs4808801 | 1 | rs4595905 | chr19:18547305 | LRRC25 | chr19:18501955-18508421:- | -0.14 | -4.81 | 2.03E-6 | Breast cancer |
| THCA | cis | rs9790314 | 1 | rs459697 | chr3:161093420 | NMD3 | chr3:160939099-160971319:+ | -0.11 | -3.58 | 0.000377 | Morning vs. evening chronotype |